Endocrine Abstracts

Introduction: The relation of hypothyroidism with the breast cancer is described early in the literature based in some common pathophysiological paths which associate thyroid gland and breast tissue.Methods: A literature research in PubMed and Cochrane library database was performed for articles studying any possible association between the risk for development of breast cancer with the presence of hypothyroidism history in women.R...

Background: Individuals with adrenal insufficiency (AI) receive life-long glucocorticoid (GC) replacement therapy (CGRT), which often exceeds normal daily physiological GC production, leading to detrimental effects on cardiometabolic parameters and bone health.Objective: Assessment of glucose, lipid and bone metabolism in AI postmenopausal patients in relation to the cause of AI and the CGRT dose.Methods: 114 AI postmenopausal wome...

Introduction: The association of thyroid disorders including autoimmune thyroiditis with the risk for breast cancer is controversial (1–4). A recent study found that triidothyronine (T3) levels are positively associated with breast cancer specific mortality (5). Experimental studies have shown that T3 mimics the effects of estrogen in human breast cell lines and induces the expression of progesterone receptors (6).Purpose: The ...

Purpose: Pheochromocytomas (PCs) and paragangliomas (PGLs) are rare neuroendocrine tumors arising from chromaffin cells of the adrenal medulla and the sympathetic/parasympathetic neural ganglia, respectively. Metastatic PCs/PGLs occur in about 5-26% of cases. Their management and diagnosis still remain a challenge due to their heterogeneity, the absence of guidelines and the few prognostic tools.Aim: The aim of this study was to describe clinical and gen...

Background: The majority of adrenal incidentalomas (AIs) are benign non-functioning adrenocortical adenomas (NFAIs), yet not clinically silent. Possible autonomous cortisol secretion (PACS) can also be diagnosed in up to 50% of patients. Endocannabinoids (ECs) have recently been studied regarding their role in the hypothalamo-pituitary-adrenocortical (HPA) axis; however, data are scarce in humans.Aim: We aimed to assess hair EC [anandamide (AEA) and 2-ar...

Introduction: Immune-check point inhibitors (ICPis) has been shown to significantly improve survival in patients with advanced melanoma. Immune-related endocrinopathies (irEs) and in particular hypophysitis and thyroid dysfunction have been well described with an incidence varying from 9–17% and 3.8–13.2% respectively.Methods: This is a retrospective analysis of irEs in 325 (190 men) patients with melanoma receiving ICPis (PD-1/PDL-1 or CTLA-4 ...

Background: Metastatic pheochromocytomas (PCs) and paragangliomas (PGLs) are rare neuroendocrine neoplasms with a <1:106 incidence, defined by the presence of metastatic disease besides recurrent or locally invasive disease.Aim: Retrospective analysis of clinical, biochemical/hormonal, imaging, genetic and histopathological features of patients with malignant PCs/PGLs diagnosed over 15 years.Results: Thirteen patient...

Introduction: Early detection of succinate dehydrogenase complex (SDH) mutations in patients with pheochromocytoma and paragaglioma (PPC/PGL) has important implications as it is associated with increased risk for malignancy. The use of negative immunohistochemical (IHC) staining for SDH subunit B, D, A (SDHB/-D/-A) has been proposed as an indicator of SDHs mutation and as an effective substitute for the high-cost genetic screening of all of these genes.M...

Introduction: CLOCK system is a highly conserved, ubiquitous molecular ‘clock’ which creates internal circadian rhythmicity under the influence of light/dark information. CLOCK system is regulated by the coordinated activation/inactivation of several transcription factors, including the CLOCK, the BMAL1 and other essential regulators, such as the Pers, Crys and RORs. The present study aimed to evaluate the circadian rhythm of clock-related genes expressed in patients...

Introduction: Glucocorticoids are used for treatment of various hematological malignancies such as Acute Myeloid Leukemia (AML). Glucocorticoids are known to induce apoptosis by regulating the expression of key anti- or pro-apoptotic genes. Vitamin D induces apoptosis and cell cycle arrest in various types of cancer cells. Despite recent advances in treatment of AML, the poor response rate to therapy remains a big challenge.Therefore, discovering new factors that can affect th...